It hasn't deepend to that point yet tough. It's still trial&error genetics and medicine. Being smarter than nature is a tall order.
I'd say the long term success (Millions of years) of humankind is still not sure. Does not seem very stable at the moment, climate change and the potential destruction via nuclear bombs and so on...
1. Nature is not "smart", it is not a conscious entity. So neither can we outsmart it nor can it outsmart us.
2. I strongly dislike the dichotomy between nature and humans. Our species is part of the natural world same as any other. Investigating into influencing or even controlling our evolution means we are making good use of our evolutionary advantages (i.e. the highly evolved brain).
I'd say the long term success (Millions of years) of humankind is still not sure. Does not seem very stable at the moment, climate change and the potential destruction via nuclear bombs and so on...