We know. But it's a problem because alcohol is one of the most dangerous and damaging drugs. It's basically just society grandfathering it in and all of us living in a state of cognitive dissonance.
re: the article itself, they concentrate only on brain regions which have high density of CB1 expression and that's reasonable. But CB1 is not the only CNS cannabinoid receptor (CB2 mostly expressed peripherally). There's also GPR55 which is activated by cannabinoids like THC. A little issue which could be addressed in future work.
I've gone to numerous tasting events where I spit out all of the wine. There may be hundreds of bottles being poured at a trade show and you can't really taste more than a handful if you are swallowing.
Patently false on both counts. There is always some level of intoxication and many people use pot to manage anxiety, pain, nausea and lack of appetite, while avoiding the high.
re: the article itself, they concentrate only on brain regions which have high density of CB1 expression and that's reasonable. But CB1 is not the only CNS cannabinoid receptor (CB2 mostly expressed peripherally). There's also GPR55 which is activated by cannabinoids like THC. A little issue which could be addressed in future work.